Colonization of adjacent stem cell compartments by mutant keratinocytes.
作者： D BRASH , W ZHANG , D GROSSMAN , S TAKEUCHI
DOI: 10.1016/J.SEMCANCER.2004.08.006
关键词: Mutagenesis (molecular biology technique) 、 Cell biology 、 Keratinocyte 、 Mutant 、 Endothelial stem cell 、 Immunology 、 Stem cell 、 Cancer stem cell 、 Adult stem cell 、 Biology 、 Apoptosis
摘要: A key step in cancer development is clonal expansion. The increased number of mutant cells allows a clinical phenotype and increases the probability that one will be mutated an additional gene. For skin cancer, observations on p53-mutant keratinocyte clones epidermal sheets UVB-irradiated mice reveal stem are normally restrained within their cell compartment. Chronic UVB exposure drives expansion by non-mutational mechanism, this mechanism to escape from own compartment colonize adjacent compartments. In absence escape, proliferate without occupying territory. appears UVB-induced apoptosis, which deletes DNA-damaged unmutated compartments but preferentially spare death-resistant cells. An source apoptotic selection pressure may come UV-irradiated melanin.
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