Electrical Stimulation Promotes Angiogenesis in a Rabbit Hind-Limb Ischemia Model:
作者： Valeri Chekanov , Ramon Rayel , David Krum , Iman Alwan , John Hare
DOI: 10.1177/153857440203600505
关键词: Internal medicine 、 Neovascularization 、 Artery 、 Blood pressure 、 Femoral artery 、 Surgery 、 Medicine 、 Ischemia 、 Muscle contraction 、 External iliac artery 、 Muscle tissue 、 Cardiology
摘要: In previous investigations, it was shown that applying a modest regimen of electrical stimulation (ES), even in severely ischemic tissue, improves the healing process, accelerates neovascularization, and enhances angiogenesis muscle tissue. Our objective this current report to further understand ES as potential alternative treatment for severe ischemia. Immediately after left distal external iliac artery femoral were excised, (30 contractions per minute [cpm], 2 V, single impulses burst) applied rabbit adductor near site excised femoralis 24 hours daily over 1 month. Three other series served controls: without arterial excision; excision or lead implantation; with implantation but no ES. Histologic study capillary density performed by angiography (employing grid template) measuring lower limb-calf blood pressure ratio. At end 30 days series, 10.5 +/-1.2 contrast-medium opacified arteries (COAs) crossed specific section segment compared 7.2 +/-1.5 control (p<0.05); 68.2 +/-9.3 COAs 43.2 +/-6.4 controls 27.3 grids contained 29.3 +/-3.5 ratio 0.81 +/-0.06 0.31 +/-0.07 283.7 +/-24.5 mm2 91.4 +/-20.9 (p<0.001). These preliminary results show cautious revascularization
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M. R. Sobotka, M. J. H. M. Jacobs, B. M. Van Der Oord, D. T. Ubbink, Effects of vacuum compression therapy on skin microcirculation in patients suffering from lower limb ischaemia. Vasa-european Journal of Vascular Medicine. ,vol. 29, pp. 53- 57 ,(2000) , 10.1024/0301-1526.29.1.53
V Ralevic, G Burnstock, Roles of P2-purinoceptors in the cardiovascular system. Circulation. ,vol. 84, pp. 1- 14 ,(1991) , 10.1161/01.CIR.84.1.1
O. Hudlická, K. Fronek, Effect of long-term electrical stimulation of rabbit fast muscles on the reactivity of their supplying arteries. Journal of Vascular Research. ,vol. 29, pp. 13- 19 ,(1992) , 10.1159/000158926
Werner Risau, Mechanisms of angiogenesis Nature. ,vol. 386, pp. 671- 674 ,(1997) , 10.1038/386671A0
Paul M. Walker, Alexander D. Romaschin, Scott Davis, John Piovesan, Lower limb ischemia: phase 1 results of salvage perfusion. Journal of Surgical Research. ,vol. 84, pp. 193- 198 ,(1999) , 10.1006/JSRE.1999.5641
Valeri S. Chekanov, Michelle A. Rieder, Guennady V. Tchekanov, Luke M. Smith, Ruben Eisenstein, Donald H. Schmidt, Comparison of Different Regimens of Electrical Stimulation Applied to Nonmobilized and Newly Mobilized Latissimus Dorsi Muscle Journal of Cardiac Surgery. ,vol. 12, pp. 343- 353 ,(1997) , 10.1111/J.1540-8191.1997.TB00149.X
O. Hudlick�, M. Brown, M. Cotter, M. Smith, G. Vrbov�, The effect of long-term stimulation of fast muscles on their blood flow, metabolism and ability to withstand fatigue. Pflügers Archiv: European Journal of Physiology. ,vol. 369, pp. 141- 149 ,(1977) , 10.1007/BF00591570
Christophe Bauters, Takayuki Asahara, Lu P Zheng, Satoshi Takeshita, Stuart Bunting, Napoleone Ferrara, James F Symes, Jeffrey M Isner, None, Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor Journal of Vascular Surgery. ,vol. 21, pp. 314- 325 ,(1995) , 10.1016/S0741-5214(95)70272-5
J Hershey, Revascularization in the rabbit hindlimb: dissociation between capillary sprouting and arteriogenesis. Cardiovascular Research. ,vol. 49, pp. 618- 625 ,(2001) , 10.1016/S0008-6363(00)00232-7
Iris Baumgartner, Ann Pieczek, Orit Manor, Richard Blair, Marianne Kearney, Kenneth Walsh, Jeffrey M. Isner, Constitutive Expression of phVEGF165 After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia Circulation. ,vol. 97, pp. 1114- 1123 ,(1998) , 10.1161/01.CIR.97.12.1114