Direct Vasoactive Effects of the Chromogranin A (CHGA) Peptide Catestatin in Humans In Vivo

摘要: Catestatin is a bioactive peptide of chromogranin A (CHGA) that co-released with catecholamines from secretory vesicles. may function as vasodilator and diminished in hypertension. To evaluate this potential vivo without systemic counterregulation, we infused catestatin to target concentrations approximately 50, 500, 5000 nM into dorsal hand veins 18 normotensive men women, after pharmacologic venoconstriction phenylephrine. Pancreastatin, another CHGA peptide, was negative control. After preconstriction 69%, increasing resulted dose-dependent vasodilation (P = 0.019), female subjects (to 44%) predominantly. The EC(50) (approximately 30 nM) for induced by the same order magnitude circulating endogenous (4.4 nM). No occurred during control infusion pancreastatin. Plasma CHGA, catestatin, CHGA-to-catestatin processing were then determined 622 healthy Female had higher plasma levels than males 0.001), yet lower precursor 0.006), reflecting increased < 0.001). Our results demonstrate dilates human blood vessels vivo, especially females. contribute sex differences vascular tone, thereby influencing complex predisposition