Hormones and Oncogenes in Human Breast Cancer

摘要: Breast cancer occurs in 120,000 women the United States annually (1). Thirty-five percent of these will ultimately die metastatic breast cancer. The majority who develop disease receive some form hormonal therapy. Effective therapies include both estrogen withdrawal by oophorectomy or leuteinizing hormone releasing (LHRH) analogues premenopausal adrenalectomy, anti-estrogens, aromatase inhibition postmenopausal women; and addition pharmacologic doses estrogens, progestins, androgens. Although 1/3 those receiving treatments have regression their disease, inevitably progession occur despite continued These facts dictate an intense study relationship between hormones growth progression cancer, mechanism which cancers independence resistance.