The impact of heparin-coated cardiopulmonary bypass circuits on pulmonary function and the release of inflammatory mediators.

摘要: Reduction of the inflammatory reaction with use heparin coating has been found during and after cardiopulmonary bypass (CPB). The question remains whether this reduced also decreases magnitude CPB-induced pulmonary dysfunction. We therefore evaluated effects a heparin-coated circuit versus similar uncoated on indices as well markers complement activation (C3b/c), elastase-alpha(1)-antitrypsin complex, secretory phospholipase A, (sPLA,) CPB. Fifty-one patients were randomly assigned into two groups undergoing coronary artery grafting either (Group 1) or an 2) circuit. During CPB, continuous positive airway pressure 5 cm H2O fraction inspired oxygen (Fio(2)) 0.21 maintained. Differences in favor coated shunt (P <0.05), vascular resistance index Pao(2)/Fio(2) ratio <0.05) CPB intensive care unit. group demonstrated lower levels sPLA(2). After C3b/c elastase-alantitrypsin complex significantly less <0.001). was associated response, decreased fraction, increased Pao2/Fio2 ratio, suggesting that may have beneficial function. correlation sPLA2, leukocyte activation, postoperative count suggests capillary endothelial cells.