Influence of glucocorticoid and mineralocorticoid receptor stimulation on task switching.
作者： Christian E. Deuter , Katja Wingenfeld , Katharina Schultebraucks , Christian Otte , Linn K. Kuehl
DOI: 10.1016/J.YHBEH.2019.01.007
关键词: Neuroscience 、 Fludrocortisone 、 Task switching 、 Cognitive flexibility 、 Glucocorticoid receptor 、 Hydrocortisone 、 Agonist 、 Mineralocorticoid receptor 、 Glucocorticoid 、 Medicine
摘要: The influence of stress on executive functions has been demonstrated in numerous studies and is potentially mediated by the stress-induced cortisol release. Yet, impact cognitive flexibility task switching particular remains equivocal. In this study, we investigated pharmacological glucocorticoid receptor (GR) mineralocorticoid (MR) stimulation, two corticosteroid types known to be responsible for effects brain. We conducted experiments, each with 80 healthy participants (40 women 40 men), tested effect unspecific MR/GR agonist hydrocortisone (Experiment I) more specific MR fludrocortisone II) switch costs rule congruency a bivalent, cued paradigm. results did not confirm our hypotheses; found no significant manipulations capacity, although general were observed. discuss absence MR/GR-mediated propose alternative mechanisms that could explain induced switching.
sci-hub.se 参考文章(63)
Katja Wingenfeld, Oliver T. Wolf, Stress, Memory, and the Hippocampus Frontiers of neurology and neuroscience. ,vol. 34, pp. 109- 120 ,(2014) , 10.1159/000356423
Dina R. Dajani, Lucina Q. Uddin, Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience. Trends in Neurosciences. ,vol. 38, pp. 571- 578 ,(2015) , 10.1016/J.TINS.2015.07.003
Leonardo José Vaz, Márcia Pradella-Hallinan, Orlando Francisco Amodeo Bueno, Sabine Pompéia, Acute glucocorticoid effects on the multicomponent model of working memory Human Psychopharmacology-clinical and Experimental. ,vol. 26, pp. 477- 487 ,(2011) , 10.1002/HUP.1230
Mégane Ribot, Andrea Polito, Stanislas Grassin-Delyle, Djillali Annane, Jean-Claude Alvarez, Human plasma quantification of fludrocortisone using liquid chromatography coupled with atmospheric pressure chemical ionization mass spectrometry after low-dosage administration. Clinica Chimica Acta. ,vol. 420, pp. 109- 113 ,(2013) , 10.1016/J.CCA.2012.11.026
Marloes J. A. G. Henckens, Guido A. van Wingen, Marian Joëls, Guillén Fernández, Time-dependent effects of cortisol on selective attention and emotional interference: a functional MRI study. Frontiers in Integrative Neuroscience. ,vol. 6, pp. 66- 66 ,(2012) , 10.3389/FNINT.2012.00066
Erno J. Hermans, Marloes J.A.G. Henckens, Marian Joëls, Guillén Fernández, Dynamic adaptation of large-scale brain networks in response to acute stressors Trends in Neurosciences. ,vol. 37, pp. 304- 314 ,(2014) , 10.1016/J.TINS.2014.03.006
B. Roozendaal, S. Okuda, D.J.-F. de Quervain, J.L. McGaugh, Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions. Neuroscience. ,vol. 138, pp. 901- 910 ,(2006) , 10.1016/J.NEUROSCIENCE.2005.07.049
Benno Roozendaal, Bruce S. McEwen, Sumantra Chattarji, Stress, memory and the amygdala Nature Reviews Neuroscience. ,vol. 10, pp. 423- 433 ,(2009) , 10.1038/NRN2651
L. Schwabe, M. Tegenthoff, O. Hoffken, O. T. Wolf, Concurrent Glucocorticoid and Noradrenergic Activity Shifts Instrumental Behavior from Goal-Directed to Habitual Control The Journal of Neuroscience. ,vol. 30, pp. 8190- 8196 ,(2010) , 10.1523/JNEUROSCI.0734-10.2010
Lars Schwabe, Hartmut Schächinger, E. Ron de Kloet, Melly S. Oitzl, Corticosteroids Operate as a Switch between Memory Systems Journal of Cognitive Neuroscience. ,vol. 22, pp. 1362- 1372 ,(2010) , 10.1162/JOCN.2009.21278