Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes
作者： Maha F. Saja , Lucie Baudino , William D. Jackson , H. Terence Cook , Talat H. Malik
DOI: 10.1016/J.CELREP.2015.08.020
关键词: Endocrinology 、 Internal medicine 、 Progenitor cell 、 Monocyte 、 CCL4 、 Hyperlipidemia 、 Bone marrow 、 Innate immune system 、 Biology 、 Extravasation 、 CD68 、 Immunology
摘要: Monocytes are heterogeneous effector cells involved in the maintenance and restoration of tissue integrity. However, their response to hyperlipidemia remains poorly understood. Here, we report that presence elevated levels triglyceride-rich lipoproteins, induced by administration poloxamer 407, blood numbers non-classical Ly6C/Gr1low monocytes drop, while number bone marrow progenitors similar. We observed an increased crawling retention Gr1low at endothelial interface a marked accumulation CD68+ macrophages several organs. Hypertriglyceridemia was accompanied expression tissue, plasma CCL4 monocyte depletion pertussis-toxin-sensitive receptor axis. Collectively, these findings demonstrate environment can alter distribution, promoting extravasation cells. The behavior dyslipidemia highlights significant impact high lipoproteins may have on innate immune
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