Molecular neurobiology of mTOR

摘要: Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that controls several important aspects mammalian cell function. mTOR activity modulated by various intra- and extracellular factors; in turn, changes rates translation, transcription, protein degradation, signaling, metabolism, cytoskeleton dynamics. has been repeatedly shown to participate neuronal development the proper functioning mature neurons. Changes are often observed nervous system diseases, including genetic diseases (e.g., tuberous sclerosis complex, Pten-related syndromes, neurofibromatosis, Fragile X syndrome), epilepsy, brain tumors, neurodegenerative disorders (Alzheimer's disease, Parkinson's Huntington's disease). Neuroscientists only recently began deciphering molecular processes downstream function system. As result, we gaining knowledge about ways which aberrant lead diseases. In this review, provide comprehensive view system, with special focus on functions control autophagy) likely underlie contribution