Gene therapy trials for the treatment of high-grade gliomas.

摘要: High-grade gliomas remain relatively resistant to current therapy. Local recurrence is a common feature and the majority of patients progress despite conventional One modality-gene therapy-has shown lot promise in early preclinical clinical studies aimed at advancing treatment this disease. In review, we provide comprehensive overview trials involving gene therapy field neuro-oncology. The use different delivery vehicles, including liposomes, cells, viruses, as well genes, especially cytokines suicide are explored detail. unique features advantages/disadvantages vectors employed compared based on results human studies. We discuss both limitations successes encountered these trials, with an emphasis lessons learned potential ways improving protocols.