Cluster of cases of Mycobacterium chelonae bacteraemia.

作者: D. McCracken , P. Flanagan , D. Hill , I. Hosein

DOI: 10.1007/S100960050008

关键词: CatheterClarithromycinAntibacterial agentOpportunistic infectionBlood cultureSurgeryMycobacterium chelonaeAntibioticsMedicineBacteremia

摘要: Mycobacterium chelonae was isolated from the blood of four immunosuppressed patients over a period 10 weeks. Three had intravascular catheters in situ and other biliary stent. All presented with recurrent fever despite treatment broad-spectrum antibiotics. Blood cultures using standard bacteriological medium yielded gram-positive bacillus each patient. Ziehl-Neelsen staining these demonstrated branching acid-fast that subsequently identified as case. The isolates were sensitive to clarithromycin and, although success monotherapy has been variable, this antibiotic combined removal used treat those three patients. successful no recurrence symptoms after 12 months follow-up. patient stent died soon isolated. Pyrolysis mass spectrometry analysis indicated two distinct strains. Radiological insertion Hickman lines implicated epidemiologically source infection.

参考文章(16)
B A Brown, R J Wallace, G O Onyi, V De Rosas, R J Wallace, Activities of four macrolides, including clarithromycin, against Mycobacterium fortuitum, Mycobacterium chelonae, and M. chelonae-like organisms. Antimicrobial Agents and Chemotherapy. ,vol. 36, pp. 180- 184 ,(1992) , 10.1128/AAC.36.1.180
K. Galil, R. Thurer, K. Glatter, T. Barlam, Disseminated Mycobacterium chelonae infection resulting in endocarditis. Clinical Infectious Diseases. ,vol. 23, pp. 1322- 1323 ,(1996) , 10.1093/CLINIDS/23.6.1322
I. I. Raad, S. Vartivarian, A. Khan, G. P. Bodey, Catheter-Related Infections Caused by the Mycobacterium fortuitum Complex: 15 Cases and Review Clinical Infectious Diseases. ,vol. 13, pp. 1120- 1125 ,(1991) , 10.1093/CLINIDS/13.6.1120
Angel M. Cutay, Harold W. Horowitz, Richard W. Pooley, Kenneth Van Horn, Gary P. Wormser, Infection of epicardial pacemaker wires due to Mycobacterium abscessus. Clinical Infectious Diseases. ,vol. 26, pp. 520- 521 ,(1998) , 10.1086/517106
PATRICIA M. FLYNN, BETTY VAN HOOSER, FRANCIS GIGLIOTTI, Atypical mycobacterial infections of Hickman catheter exit sites. Pediatric Infectious Disease Journal. ,vol. 7, pp. 510- 513 ,(1988) , 10.1097/00006454-198807000-00014
C. W. Ingram, D. C. Tanner, D. T. Durack, G. W. Kernodle, G. R. Corey, Disseminated Infection with Rapidly Growing Mycobacteria Clinical Infectious Diseases. ,vol. 16, pp. 463- 471 ,(1993) , 10.1093/CLIND/16.4.463
Jay D Wenger, John S Spika, Ronald W Smithwick, Vickie Pryor, David W Dodson, G Alexander Carden, Karl C Klontz, Outbreak of Mycobacterium chelonae Infection Associated With Use of Jet Injectors JAMA: The Journal of the American Medical Association. ,vol. 264, pp. 373- 376 ,(1990) , 10.1001/JAMA.1990.03450030097040
D. M. Mushatt, R. S. Witzig, Successful Treatment of Mycobacterium abscessus Infections with Multidrug Regimens Containing Clarithromycin Clinical Infectious Diseases. ,vol. 20, pp. 1441- 1442 ,(1995) , 10.1093/CLINIDS/20.5.1441
Leonard F. Laskowski, J. Joseph Marr, John F. Spernoga, Norma J. Frank, Hendrick B. Barner, George Kaiser, Denis H. Tyras, Fastidious Mycobacteria Grown from Porcine Prosthetic-Heart-Valve Cultures The New England Journal of Medicine. ,vol. 297, pp. 101- 102 ,(1977) , 10.1056/NEJM197707142970209