Selection signatures in two oldest Russian native cattle breeds revealed using high-density single nucleotide polymorphism analysis.

摘要: Native cattle breeds can carry specific signatures of selection reflecting their adaptation to the local environmental conditions and response breeding strategy used. In this study, we comprehensively analysed high-density single nucleotide polymorphism (SNP) genotypes characterise population structure detect in Russian native Yaroslavl Kholmogor dairy breeds, which have been little influenced by introgression with transboundary breeds. Fifty-six samples pedigree-recorded purebred animals, originating from different farms representing sire lines, two studied were genotyped using a genome-wide bovine genotyping array (Bovine HD BeadChip). Three statistical analyses-calculation fixation index (FST) for each SNP comparison pairs hapFLK analysis, estimation runs homozygosity (ROH) islands shared more than 50% animals-were combined detecting genome We confirmed nine six known regions under putative genomes cattle, respectively; flanking positions most these elucidated. Only selected (localised on BTA 14 at 24.4-25.1 Mbp 16 42.5-43.5 Mb) overlapped Yaroslavl, Holstein addition, detected three novel sweeps (BTA 4 4.74-5.36 Mbp, 15 17.80-18.77 17 45.59-45.61 Mbp) 12 82.40-81.69 16.04-16.62 18 0.19-1.46 least above-mentioned methods. expanded list candidate genes associated genomic performed functional annotation. discussed possible involvement identified artificial connection origin development Our findings obtained methods allowed detection that might be selection. These results useful sustainable conservation oldest