Long-term administration of highly purified eicosapentaenoic acid provides improvement of psoriasis.

摘要: Nine patients with chronic stable psoriasis (4 males and 5 females) were entered in this trial. Eicosapentaenoic acid (EPA) ethylester (90% pure) without docosahexaenoic (DHA) gelatin-coated capsules at a daily dose of 3.6 g was administered to 9 for 3 months, 7 6 months 12 months. The clinical changes skin lesions the treatment as follows: marked improvement 1, relative 1 no change 1. A first observed 2–3 after EPA treatment. supplementation highly purified caused significant increase content plasma docosapentaenoic affecting that arachidonic (AA) DHA. decreased production leukotriene B4 (LTB4) increased formation B5 (LTB5) 5-hydroxyeicosapentaenoic significantly A23187-stimulated neutrophils. LTB5/LTB4 ratio positively correlated EPA/A directionally related score, although directional data not statistically significant. We could observe any side effects over year. Although its are modest, it is nontoxic favorable effect appears continue duration usage, indicating be beneficial long-term psoriasis.