Primary sclerosing cholangitis with normal serum alkaline phosphatase activity
作者： Kumaravelu Balasubramaniam , Russell H. Wiesner , Nicholas F. LaRusso
DOI: 10.1016/0016-5085(88)90378-2
关键词: Inflammatory bowel disease 、 Medicine 、 Alkaline phosphatase 、 Cholangiography 、 Internal medicine 、 Cirrhosis 、 Fibrosis 、 Liver disease 、 Gastroenterology 、 Pathology 、 Primary sclerosing cholangitis 、 Concomitant
摘要: We report 12 cases of primary sclerosing cholangitis (confirmed by cholangiography) in which the serum alkaline phosphatase activity was normal. The enzyme remained normal during follow-up 7 and fluctuated 5 (it returned to 4). presence advanced histologic stage (fibrosis/cirrhosis) with marked cholangiographic changes 4 patients establishes that cirrhotic-stage can occur without a concomitant increase activity. Therefore, may exist an occult state symptoms or Our findings suggest be more prevalent than realized, especially who have inflammatory bowel disease. A value for should not preclude further investigation disease when signs liver
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