Salivary Peptide Tyrosine–Tyrosine 3–36 Modulates Ingestive Behavior without Inducing Taste Aversion

摘要: Hormone peptide tyrosine–tyrosine (PYY) is secreted into circulation from the gut L-endocrine cells in response to food intake, thus inducing satiation during interaction with its preferred receptor, Y2R. Clinical applications of systemically administered PYY for purpose reducing body weight were compromised as a result common side effect visceral sickness. We describe here novel approach elevating saliva mice, which, although reliably strong anorexic responses, does not cause aversive reactions. The augmentation salivary activated forebrain areas known mediate feeding, hunger, and while minimally affecting brainstem chemoreceptor zones triggering nausea. By comparing neuronal pathways by systemic versus PYY, we identified metabolic circuit associated Y2R-positive oral cavity extending through nuclei hypothalamic satiety centers. discovery this alternative that regulates ingestive behavior without taste aversion may open possibility therapeutic application treatment obesity via direct application.