作者: Michael R. Gillings , Ian T. Paulsen , Sasha G. Tetu
DOI: 10.1111/NYAS.13268
关键词: Resistome 、 Genetics 、 Global problem 、 Gene 、 Mobile genetic elements 、 Antibiotic resistance 、 Resistance (ecology) 、 Computational biology 、 Biology 、 Experimental evolution 、 Genomics 、 General Biochemistry, Genetics and Molecular Biology 、 History and philosophy of science
摘要: Antibiotic resistance arises as a consequence of complex interactions among genes, mobile elements, and their bacterial hosts, coupled with the intense selection pressures imposed by humans in an attempt to control bacterial growth. Understanding the evolution of resistance requires an understanding of interacting cellular and genetic components. Here, we review how DNA analysis has helped reconstruct the origins of the mosaic, multiresistant mobile elements that have spread through pathogens in the last 60 years. This history helps inform …