Genomics and the evolution of antibiotic resistance

作者: Michael R. Gillings , Ian T. Paulsen , Sasha G. Tetu

DOI: 10.1111/NYAS.13268

关键词: ResistomeGeneticsGlobal problemGeneMobile genetic elementsAntibiotic resistanceResistance (ecology)Computational biologyBiologyExperimental evolutionGenomicsGeneral Biochemistry, Genetics and Molecular BiologyHistory and philosophy of science

摘要: Antibiotic resistance arises as a consequence of complex interactions among genes, mobile elements, and their bacterial hosts, coupled with the intense selection pressures imposed by humans in an attempt to control bacterial growth. Understanding the evolution of resistance requires an understanding of interacting cellular and genetic components. Here, we review how DNA analysis has helped reconstruct the origins of the mosaic, multiresistant mobile elements that have spread through pathogens in the last 60 years. This history helps inform …

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