The photophysicochemical properties and photodynamic therapy activity of In and Zn phthalocyanines when incorporated into individual or mixed Pluronic® micelles
作者： Banele Mike Motloung , Balaji Babu , Earl Prinsloo , Tebello Nyokong , None
DOI: 10.1016/J.POLY.2020.114683
关键词: Octanol 、 Chemistry 、 Dimethyl sulfoxide 、 Poloxamer 、 Zinc 、 Nuclear chemistry 、 Micelle 、 Singlet oxygen 、 Benzothiazole 、 Photodynamic therapy
摘要: Abstract The synthesis, photophysicochemical properties and photodynamic activity (PDT) of tetra-pyridyloxy (1,2) benzothiazole (3, 4) substituted indium (III) (1,3) zinc (2, phthalocyanines (Pcs) their incorporation into Pluronic® F127 Pluronic L121/F127 mixed micelles (the latter for 3 4 only) are presented in this study. InPcs exhibited higher singlet oxygen (ΦΔ) at 0.76 0.68 compared to the ZnPc’s 0.47 0.44 dimethyl sulfoxide. ΦΔ values presence water, were 0.39 0.42 0.23 0.37 ZnPc. F127/L121 complex 0.51 0.29 water. Kp was determined using water octanol system. had larger suggesting that they more likely be taken up by cancer cells hence showed better PDT activity.
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