The role of cannabinoids and leptin in neurological diseases.

作者: E. Agar

DOI: 10.1111/ANE.12411

关键词: LeptinEndocannabinoid systemCannabinoid Receptor AgonistsNeuroprotectionCannabinoidNeuroscienceMultiple sclerosisLeptin receptorBiologyCannabinoid receptor

摘要: Cannabinoids exert a neuroprotective influence on some neurological diseases, including Alzheimer's, Parkinson's, Huntington's, multiple sclerosis and epilepsy. Synthetic cannabinoid receptor agonists/antagonists or compounds can provide symptom relief control the progression of diseases. However, molecular mechanism effectiveness these agents in controlling most diseases remain unclear. may effects via number mechanisms interactions with neurotransmitters, neurotropic factors neuropeptides. Leptin is peptide hormone involved regulation food intake energy balance its actions specific hypothalamic nuclei. receptors are widely expressed throughout brain, especially hippocampus, basal ganglia, cortex cerebellum. has also shown properties disorders, such as Parkinson's Alzheimer's. Therefore, leptin hold therapeutic potential for Further elucidation underlying lead to development new strategies treatment disorders.

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