Assessment of Microelastic Properties of Bone Using Scanning Acoustic Microscopy: A Face-to-Face Comparison with Nanoindentation
作者： Fabienne Rupin , Amena Saïed , Davy Dalmas , Françoise Peyrin , Sylvain Haupert
关键词: Composite material 、 Bone mineral 、 Materials science 、 Mineralogy 、 Acoustic impedance 、 Elastic modulus 、 Acoustic microscopy 、 Elasticity (economics) 、 Nanoindentation 、 Modulus 、 Cortical bone
摘要: The current work aimed at comparing, on site-matched cortical bone tissue, the micron-level elastic modulus Ea derived from 200 MHz-scanning acoustic microscopy (SAM) impedance (Z) combined with mineral density (assessed by synchrotron radiation microcomputed tomography, SR-µCT) to nanoindentation En. A good correlation was observed between En and Z (R2=0.67, p<0.0001, root mean square error RMSE=1.9 GPa). acoustical showed higher values of E compared moduli. We assumed that discrepancy may likely be due fixed value Poisson's ratio while comprised 0.15 0.45 have been reported in literature. Despite these differences, a highly significant found (R2=0.66, p<0.001, RMSE=1.8 GPa) suggesting SAM can reliably used as modality quantitatively map local variations tissue-level elasticity.
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