作者: Youngsup Song , Roger D. Cone
关键词: Internal medicine 、 Melanocortin receptor 、 Melanocortin 、 Biology 、 Zebrafish 、 Genetic model 、 Transgene 、 Endocrinology 、 Central melanocortin system 、 Energy homeostasis 、 Leptin
摘要: The adipostat is the mechanism by which brain detects and maintains constant levels of energy stored in adipocytes form lipids. Key elements include adipocyte-derived hormone leptin that expressed proportion to serves communicate this information central nervous system circuits, sense respond leptin. Blockade one these melanocortin system, disrupts action causes a distinct obesity syndrome mice humans, characterized increased adiposity as well linear growth. We show here transgenic zebrafish overexpressing endogenous antagonist agouti-related protein (AgRP) also exhibit obesity, growth, adipocyte hypertrophy. These findings demonstrate key originated before evolution mammals. Furthermore, overexpression AgRP yields new model for ...