Creation of a genetic model of obesity in a teleost

作者: Youngsup Song , Roger D. Cone

DOI: 10.1096/FJ.06-7503COM

关键词: Internal medicineMelanocortin receptorMelanocortinBiologyZebrafishGenetic modelTransgeneEndocrinologyCentral melanocortin systemEnergy homeostasisLeptin

摘要: The adipostat is the mechanism by which brain detects and maintains constant levels of energy stored in adipocytes form lipids. Key elements include adipocyte-derived hormone leptin that expressed proportion to serves communicate this information central nervous system circuits, sense respond leptin. Blockade one these melanocortin system, disrupts action causes a distinct obesity syndrome mice humans, characterized increased adiposity as well linear growth. We show here transgenic zebrafish overexpressing endogenous antagonist agouti-related protein (AgRP) also exhibit obesity, growth, adipocyte hypertrophy. These findings demonstrate key originated before evolution mammals. Furthermore, overexpression AgRP yields new model for ...

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