Solid pharmaceutical composition for oral administration
作者： Yoshio Tanizawa , Masato Kozaki
DOI:
关键词: Oral administration 、 Malic acid 、 Benzoic acid 、 Tartaric acid 、 Ascorbic acid 、 Organic chemistry 、 Chemistry 、 Acetamide 、 Organic acid 、 Salt (chemistry)
摘要: Disclosed is a solid pharmaceutical composition for oral administration, which contains (A) 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide (compound (a)) or an acid addition salt thereof, and (B) organic selected from among tartaric acid, malic ascorbic benzoic acid. The administration has improved dissolvability of the compound (a) that useful as therapeutic agent hypercholesterolemia, arteriosclerosis like.
google.it 参考文章(10)
Kimiyuki Shibuya, Tadaaki Ohgiya, Takayuki Matsuda, Process for producing acid adduct salt of polyacidic base compound ,(2004)
Toshiyuki Edano, Katsumi Kawamine, Mitsuteru Hirata, Chiyoka Ozaki, Yukihiro Sato, Kimiyuki Shibuya, Toru Miura, Novel cyclic diamine compounds and medicine containing the same ,(1998)
Yasunobu Yoshinaka, Kimiyuki Shibuya, Hideyuki Kobayashi, Method of stabilizing lipid-rich plaque and method of preventing rupture thereof ,(2004)
Mami Ikenoya, Yasunobu Yoshinaka, Hideyuki Kobayashi, Katsumi Kawamine, Kimiyuki Shibuya, Fumiyasu Sato, Kimio Sawanobori, Takuya Watanabe, Akira Miyazaki, A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels Atherosclerosis. ,vol. 191, pp. 290- 297 ,(2007) , 10.1016/J.ATHEROSCLEROSIS.2006.05.048
Kimiyuki Shibuya, Ayako Tosaka, Method for producing cyclic diamine derivative ,(2005)
Tadaaki Ohgiya, Kimiyuki Shibuya, Toru Miura, Method for producing cyclic diamine derivative or salt thereof ,(2004)
Tadaaki Ohgiya, Yukihiro Sato, Kimiyuki Shibuya, Toru Miura, Processes for production of cyclic diamine compounds or salts thereof ,(2002)
Tadaaki Ohgiya, Kimiyuki Shibuya, Toru Miura, Hydroxyalkylated cyclic diamine compound ,(2003)
Bureda Meden, Tsudorabuko Kopitaru, Mariya Ramupuretsuto, Jienii Mirobuatsuku, Andorei Renarudeitsuku, Boyan Kofuraa, Yanya Urubanshitsukuusumerukor, Miruyan Tsuorutsu, Mateya Kobuashitsuku, Buida Nikoritsuku, Anjiera Bueneemojina, DISPERSING TABLET OF DIHYDROERGOTOXINE OR ITS ACID-ADDED SALT AND MANUFACTURE OF SAID TABLET ,(1990)
Gotsutofuriito Shiepuki, Buirii Rooto, Peetaa Guruuberu, ORAL ADMINISTRATING PREPARATION OF PIMOBENDAN ,(1992)