Engineered biosynthesis of natural products in heterologous hosts

作者: Yunzi Luo , Bing-Zhi Li , Duo Liu , Lu Zhang , Yan Chen

DOI: 10.1039/C5CS00025D

关键词: GenomeBiochemistryBiologyBiosynthesisTerpenoidMetabolic engineeringTerpeneHeterologousMicrobial metabolismGene

摘要: Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native …

参考文章(189)
Dejana Jovicevic, Benjamin A. Blount, Tom Ellis, Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast BioEssays. ,vol. 36, pp. 855- 860 ,(2014) , 10.1002/BIES.201400086
Yong Wang, Effendi Leonard, Gregory Stephanopoulos, Too Heng Phon, Keith E. J. Tyo, Blaine Pfeifer, Oliver Mucha, Fritz Simeon, Parayil Kumaran Ajikumar, Wen-Hai Xiao, Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli PubMed Central. ,(2010)
Elena Fossati, Andrew Ekins, Lauren Narcross, Yun Zhu, Jean-Pierre Falgueyret, Guillaume A. W. Beaudoin, Peter J Facchini, Vincent J. J. Martin, Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae Nature Communications. ,vol. 5, pp. 3283- 3283 ,(2014) , 10.1038/NCOMMS4283
Wei Xu, Xiaolu Cai, Michael E. Jung, Yi Tang, Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. Journal of the American Chemical Society. ,vol. 132, pp. 13604- 13607 ,(2010) , 10.1021/JA107084D
R. G. Egbert, E. Klavins, Fine-tuning gene networks using simple sequence repeats Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 16817- 16822 ,(2012) , 10.1073/PNAS.1205693109
Yongjin J. Zhou, Wei Gao, Qixian Rong, Guojie Jin, Huiying Chu, Wujun Liu, Wei Yang, Zhiwei Zhu, Guohui Li, Guofeng Zhu, Luqi Huang, Zongbao K. Zhao, Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. Journal of the American Chemical Society. ,vol. 134, pp. 3234- 3241 ,(2012) , 10.1021/JA2114486
C. Kao, L Katz, C Khosla, Engineered biosynthesis of a complete macrolactone in a heterologous host Science. ,vol. 265, pp. 509- 512 ,(1994) , 10.1126/SCIENCE.8036492
Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan, Synthetic microbial consortia: from systematic analysis to construction and applications Chemical Society Reviews. ,vol. 43, pp. 6954- 6981 ,(2014) , 10.1039/C4CS00114A
Mohammad A. Asadollahi, Jérôme Maury, Michel Schalk, Anthony Clark, Jens Nielsen, Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae Biotechnology and Bioengineering. ,vol. 106, pp. 86- 96 ,(2010) , 10.1002/BIT.22668