In vitro method for prognosis and/or diagnosis of hypersensitivity to ooestrogens or to substances with ooestrogenic activity
作者： Luis Miguel Real , Ana Salinas , Laza Agustin Ruiz , Civantos Francisco Jesus Moron , Goni Maria Eugenia Saez
DOI:
关键词: Estrogen receptor alpha 、 In vitro 、 Oligonucleotide 、 Intron 、 Oestrogen receptor 、 Gene 、 Nucleotide 、 Molecular biology 、 Biology
摘要: In vitro method for prognosis and/or diagnosis of hypersensitivity to oestrogens or substances with oestrogenic activity. The is based on the detection presence absence a deletion 2244 nucleotides at intron 6 human gene alpha oestrogen receptor (ESR1), which deletion, if present, signifies an increase in probability that individual hypersensitive activity, determination nucleotide present location corresponding least one polymorphism said selected from rs851995, rs3020314 and rs910416. invention also relates oligonucleotides are useful detecting variants gene, kits enable be implemented use variant ESR1 exhibits oestrogen.
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