Facile synthesis of aryl(difluoromethyl)phosphonates through CuBr-mediated cross coupling reactions of [(diethoxyphosphinyl)difluoromethyl]zinc bromide with aryl iodides
作者： Tsutomu Yokomatsu , Tetsuo Murano , Kenji Suemune , Shiroshi Shibuya
DOI: 10.1016/S0040-4020(96)01063-0
关键词: Organic chemistry 、 Phosphonate 、 Free acid 、 Structural isomer 、 Medicinal chemistry 、 Chemistry 、 Naphthalene 、 Coupling reaction 、 Zinc bromide 、 Aryl
摘要: Abstract The CuBr-promoted coupling reaction of [(diethoxyphosphinyl)difluoromethyl]zinc bromide 6 with aryl iodides in either DMF or DMA was examined to give a series aryl(difluoromethyl)phosphonates. applicable the selective synthesis α,α-difluoro-4- iodobenzylphosphonale 11e, useful intermediate for preparation F2Pmp. 1-[(Diethylphosphono)difluoromethyl] naphthalene 15 and regioisomer 16 were obtained high yields from 1- 2-iodonaphthalene, respectively. phosphonate transformed free acid 4a, low molecular-mass inhibitor protein phosphatases.
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