Multifrequency high precise subTHz-THz-IR spectroscopy for exhaled breath research

作者: Vladimir L. Vaks , Elena G. Domracheva , Sergey I. Pripolzin , Mariya B. Chernyaeva

DOI: 10.1117/12.2236686

关键词: Biomedical engineeringMedical diagnosticThz spectroscopyNuclear magnetic resonanceInfrared spectroscopySpectroscopyTerahertz spectroscopy and technologyHealthy volunteersGas analyzer

摘要: Nowadays the development of analytical spectroscopy with high performance, sensitivity and spectral resolution for exhaled breath research is attended. The method two-frequency precise THz subTHz-THz-IR are presented. Development a gas analyzer increases number gases that can be identified reliability detection by confirming signature in both MIR ranges. testing measurements have testified this new direction to open widespread trends its using various problems medicine biology. First all, there laboratory investigations processes studying their dynamics. Besides, methods presented applied detecting intermediate short time living products reactions breath. spectrometers been employed acetone, methanol ethanol samples healthy volunteers diabetes patients. results demonstrated an increased concentration acetone dynamic changing before after taking medicines discovered. potential markers pre-cancer states oncological diseases gastrointestinal tract organs detected. changes NO cancer patients during radiotherapy as well increase NH3 at revealed. preliminary biomarkers three frequency ranges advantages multifrequency noninvasive medical diagnostics.

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