Tansmucosal drug delivery system

摘要: Disclosed are preparations and formulations of high thermodynamic activity lipophilic associations (LA), in which there is pairing between an ionizable pharmaceutical agent a species having ionic characteristics opposite to that the agent. Such manifest activity, as evidenced by their being predominantly liquid phase at room temperature or solvated lower-than-water dielectric solvent. Further solubilized means dissolution not rate limiting transmucosal absorption. This LA LA-solvate formulated into low dosage form, from whence, upon form's hydration, driven through mucosal tissue systemic circulation. The invention therefore provides enhanced drug delivery system for agents near physiological pH.