Water-soluble chitosan derivatives as a BACE1 inhibitor
作者： Jae-Young Je , Se-Kwon Kim
DOI: 10.1016/J.BMC.2005.07.004
关键词: Water soluble chitosan 、 Enzyme inhibitor 、 Enzyme 、 Chemical modification 、 Biological activity 、 Nuclear chemistry 、 Solubility 、 Organic chemistry 、 Nuclear magnetic resonance spectroscopy 、 Chemistry 、 Chitosan
摘要: BACE1 (the beta-site APP-cleaving enzyme) inhibitory activities of water-soluble chitosan derivatives substituted with aminoethyl, dimethylaminoethyl and diethylaminoethyl groups were investigated. AE-chitosan (90%) prepared from 90% deacetylated showed the strongest activity than those other derivatives. The pattern was found to be non-competitive by Dixon plot, value inhibition constant (K(i)) 85 microg/mL.
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