Drug delivery matrices to enhance wound healing
作者： Franz Weber , Jeffrey Alan Hubbell , Jason C. Schense , Hugo Schmoekel
DOI:
关键词: Drug delivery 、 Cystine knot 、 Growth factor 、 Wound healing 、 Molecule 、 In vitro 、 Materials science 、 Combinatorial chemistry 、 Solubility 、 In vivo
摘要: Bioactive molecules are entrapped within a matrix for the controlled delivery of these compounds therapeutic healing applications. The may be formed natural or synthetic compounds. primary method entrapment bioactive molecule is through precipitation during gelation matrix, either in vitro vivo. modified to reduce its effective solubility retain it more effectively such as deglycosylation members cystine knot growth factor superfamily and particularly TGFβ superfamily. include sites with binding affinity different molecules, example, heparin binding.
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