Mucosal vaccination against enteric pathogens in the developing world.

摘要: Of the approximately 9 million children under age of 5 yr that die annually in developing nations, about 5.1 will from preventable infectious diseases. This disastrous human and economic loss is caused large part by three types acute diarrhea attendant respiratory tract infections are responsible for 2.6 these deaths. Thus, enteric pathogens remain a major factor contributing to persistent poverty poor health nations. Novel mucosal vaccination strategies emerging can protect epithelial surfaces therefore promise simple, effective safe interventional therapy overcome mortality generated debilitating Before full potential against diseases be realized, innate immune system must strengthen addressing secondary problems such as malnutrition, malabsorption gastrointestinal impairment. Here we describe childhood morbidity resource-limited countries. We also discuss development when combined with modern principles Review Article British Journal Medicine & Medical Research, 2(3): 260-291, 2012 261 nutritional may help improve socio-economic status