Association between SNPs of MnSOD, CAT, and GPX1 and exposures that impact oxidative stress on the risk of prostate cancer.

摘要: Fifth AACR International Conference on Frontiers in Cancer Prevention Research, Nov 12-15, 2006 B196 Oxidative stress appears to be a risk factor for prostate cancer. Thus, we evaluated potential associations between and gene variants that result reduced neutralization of reactive oxygen species (ROS) ( MnSOD Ala-9Val, CAT -262 C>T, GPX1 -198 C>T) the Carotene Retinol Efficacy Trial (CARET) cohort, among which there were 737 incident cancers after an average follow up 11 years. Odds ratios (OR) and95% confidence intervals (95% CI) estimated by logisticregression. In nested case-controls analyses based 546 cases 1,474 controls matched race, age, length follow-time with DNA available, findings differed little genotypes , or overall stratified analyses. However, when calculating number alleles (reduced protection against ROS), men more than 4 had significantly increased cancer compared less 5 (adjusted OR=2.5, 95% CI=1.10-5.73). Results strongest greater exposure sources oxidative stress, who heavy smokers (> 60 packyears) (OR=4.1, CI=1.06-15.53), higher consumers alcoholic beverages (OR=5.0, CI=1.72-14.27), non-users vitamin supplements (OR=3.2, CI=1.07-9.88). These results indicate SNPs genes relevant ROS may play important role development cancer, particularly ROS.