Normal intelligence in children with prenatal exposure to carbamazepine

摘要: Objective: To investigate the effect of antiepileptic drugs, especially carbamazepine and valproate, on intelligence in prenatally exposed children mothers with epilepsy. Methods: Intelligence 182 epilepsy (study group) 141 control was tested a blinded setting at preschool or school age using Wechsler Preschool Primary Scale Intelligence–Revised for Children–Revised. Data maternal treatment seizures during pregnancy were gathered prospectively. The study group represented approximately 50% born to Uusimaa province 1989 through1994. One hundred seven monotherapy: 86 13 valproate. Thirty polytherapy: 23 combinations included carbamazepine, 17 median doses blood levels second half 600 mg 26 μmol/L 950 300 Results: mean verbal nonverbal IQ scores utero monotherapy 96 (95% CI, 93–100) 103 100–106). They did not differ from subjects, whose 95 92–97) 102 100–105). Significantly reduced found valproate (mean, 82; 95% 78–87) polytherapy 85; 80–90) compared other subjects. Conclusions: Carbamazepine serum within reference range does impair offspring. Exposures associated significantly intelligence. independent effects remain unconfirmed because results confounded by low education polytherapy.