Environmentally relevant levels of λ-cyhalothrin, fenvalerate, and permethrin cause developmental toxicity and disrupt endocrine system in zebrafish (Danio rerio) embryo.

摘要: Abstract Synthetic pyrethroids (SPs) are one of the most widely used pesticides and frequently detected in aquatic environment. Previous studies have shown that SPs posed high toxicity, but information on developmental toxicity endocrine disruption zebrafish ( Danio rerio ) at environmentally relevant concentrations is limited. In this study, embryos were employed to examine adverse effects λ-cyhalothrin (LCT), fenvalerate (FEN), permethrin (PM) 2.5, 10, 25, 125, 500 nM for 96 h. The results showed these 3 caused dose-dependent mortality, malformation rate, hatching rate. Thyroid hormone triiodothyronine (T levels significantly decreased after exposure LCT FEN. Quantitative real-time PCR analysis was then performed a series nuclear receptors NRs genes involved hypothalamic–pituitary–gonadal (HPG), hypothalamic–pituitary–thyroid (HPT), hypothalamic–pituitary–adrenocortical (HPA) axes, oxidative-stress-related system. Our LCT, FEN, PM downregulated AR expression while upregulated ER1 expression, alteration ER2a ER2b expression. As TRα TRβ , they both following SPs. MR FEN induced addition, GR increased treating with it suppressed PM. also various alterations including AhRs PPARα PXR . These findings suggest may cause larvae by disrupting signaling concentrations.