Histone Deacetylase Inhibitors for Selective Anti-Cancer Therapeutics
作者： Shambhunath Choudhary
DOI:
关键词: Cytotoxic T cell 、 Cancer research 、 HDAC11 、 Cancer 、 Chemistry 、 Histone deacetylase 2 、 Cancer cell 、 Histone deacetylase 5 、 Histone deacetylase 、 Regulation of gene expression
摘要: More than 35% of human urinary bladder cancers involve oncogenic H-Ras activation. In addition to tumorigenic ability, possesses a novel pro-apoptotic ability facilitate the induction apoptosis by histone deacetylase inhibitors (HDACIs). HDACIs are new class anticancer agents and highly cytotoxic transformed cells. To understand connection between selectivity on cells HDACI-induced apoptosis, we introduced into J82 cancer mimic an acquisition H-ras gene activation in tumor development. Expression promoted acquire ability.
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