Caveolin-1 and caveolin-2,together with three bone morphogenetic protein-related genes, may encode novel tumor suppressors down-regulated in sporadic follicular thyroid carcinogenesis.

摘要: Thyroid cancer is common, occurring in 1% of the general population. The relative frequencies two most common subtypes thyroid carcinoma, follicular (FTC) and papillary (PTC), vary depending on regional prevalence iodine deficiency. Although PTC has been more extensively studied, etiology sporadic FTC poorly understood. To further elucidate this, we conducted microarray expression comparison tumors normal tissue. Three commonly down-regulated genes, caveolin-1, caveolin-2, GDF10/BMP3b, were chosen for study basis their localization to chromosomal regions, 7q31.1 10q11.1, that show loss heterozygosity FTC. Two additional glypican-3 a novel chordin-like gene, also analyzed view involvement bone morphogenetic protein signaling possible interaction with GDF10. Each these five genes was ≥15 19 (79%) by semiquantitative reverse transcription-PCR. Caveolin-1 showed preferential down-regulation its β-isoform at both mRNA level, suggesting distinct function this isoform. particular functional interest because it shown interact PTEN, tumor suppressor gene mutated Cowden syndrome, an inherited multiple hamartoma syndrome includes predisposition Immunohistochemical analysis 141 various histological types significantly fewer caveolin-1-positive FTCs, including insular type tumors, Hurthle cell carcinomas thyroid. anaplastic did not significant down-regulation, thus, caveolin-1 may become useful molecular marker differentiate histologies malignancies.