Molecular Targets of Chemical Mutagens
作者： Bradley D. Preston , Rupa Doshi
DOI: 10.1007/978-1-4684-5877-0_20
关键词: Chemistry 、 Chemical mutagens 、 Biochemistry 、 DNA 、 RNA 、 Molecular targets
摘要: Most mutagens are biologically active by virtue of their chemical reactivity. The pioneering work the Millers (reviewed in Miller and Miller, 1974, 1981) others (Searle, 1984 references therein) clearly established that most (or metabolites) electrophilic covalently bind to cellular macromolecules. Proteins were first identified as targets (Miller, 1951), it was soon recognized RNA DNA also extensively damaged (for reviews see: Searle, 1984; 1974). Theoretically, every nucleophile is a potential target for damage mutagens.
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