Calibration of the 125I-induced x-ray fluorescence spectrometry-based system of in vivo bone strontium determinations using hydroxyapatite as a phantom material: a simulation study.

摘要: The calibration of in vivo X-ray fluorescence systems bone strontium quantification, based on 125I excitation, is dependent a coherent normalization procedure. Application this procedure with the use plaster Paris (poP) as phantom material requires application conversion factor (CCF) to make functions transferable between and human bone. In work we evaluate, Monte Carlo simulation, potential benefit employing newly developed hydroxyapatite into protocol. Simulations being performed bare phantoms, emission spectrum case equivalent an adequately corrected measurement for soft tissue attenuation emitted signal. We report that phantoms does fact remove need correction (CCF). can thus be used removing one step Calibration however limited cases which concentration relative amount calcium specimen, is, most useful quantity clinical sense. Determining concentrations per-mass-of-material basis, not normalized content phantom/bone, results large biases estimated content. HAp was found CCF. It also incomplete ratio when preparing there would little effect differential cross-section thereby normalization-based