Cardiovascular toxicity of novel psychoactive drugs: Lessons from the past
作者： Patrick Dawson , James D. Moffatt
DOI: 10.1016/J.PNPBP.2012.05.003
关键词: Agonist 、 Ecstasy 、 Psychology 、 Substance abuse 、 Stimulant 、 MDMA 、 TCB-2 、 Pharmacology 、 Dopamine 、 Hallucinogen 、 Biological psychiatry
摘要: The long use of ephedrine, amphetamines, cocaine, LSD and more recently 3,4-methylenedioxy-N-methylamphetamine (MDMA; "Ecstasy") allows us to predict with some confidence what cardiovascular risks are likely be associated novel psychoactive substances (NPS). Once the probably multiple biological activities a compound known it is possible define toxicity. Agonists 5-HT(2A) receptors or alpha-adrenoceptors may cause vasoconstriction tissue ischemia. Drugs which have agonist affinity for 5-HT(2B) will promote heart valve fibrosis leading failure. Compounds that interfere uptake dopamine 5-hydroxytryptamine (5-HT) also effects on noradrenergic neurotransmission lead sympathomimetic vasculature. release, inhibit addictive chronic use. Other drugs (particularly so-called empathogens) weekly usage in social settings; over time such can harm. Defining these NPS an important element predicting harm they informing those appointed introduce regulations control them.
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