Blockage of the HERG human cardiac K+ channel by the gastrointestinal prokinetic agent cisapride
作者： Saeed Mohammad , Zhengfeng Zhou , Qiuming Gong , Craig T. January
DOI: 10.1152/AJPHEART.1997.273.5.H2534
关键词: K channels 、 Cisapride 、 Torsades de pointes 、 Prokinetic agent 、 Potassium channel 、 Medicine 、 Cellular mechanism 、 QT interval 、 hERG 、 Pharmacology
摘要: Cisapride, a gastrointestinal prokinetic agent, is known to cause long Q-T syndrome and ventricular arrhythmias. The cellular mechanism not known. humanether-a-go-go-related gene (HERG), whi...
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