Long-Lived Polymer-Supported Dimeric Cinchona Alkaloid Organocatalyst in the Asymmetric α-Amination of 2-Oxindoles
作者： Ravindra P. Jumde , Alessandro Mandoli
关键词: Enantiomer 、 Alkaloid 、 Catalysis 、 Polystyrene 、 Organic chemistry 、 Diethyl azodicarboxylate 、 Cinchona 、 Enantioselective synthesis 、 Amination 、 Chemistry
摘要: Nearly quantitative yields and high enantiomeric purity (89–95% ee) were attained in the course of 100 reaction cycles a polystyrene resin-supported Cinchona alkaloid organocatalyst enantioselective α-amination 2-oxindoles with diethyl azodicarboxylate. The catalytic material proved stable for >5300 h operation time over 8 months.
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