The Ikappa B-NF-kappa B Signaling Module: Temporal Control and Selective Gene Activation

摘要: Nuclear localization of the transcriptional activator NF-κB (nuclear factor κB) is controlled in mammalian cells by three isoforms inhibitor protein: IκBα, -β, and -ɛ. Based on simplifying reductions IκB–NF-κB signaling module knockout cell lines, we present a computational model that describes temporal control activation coordinated degradation synthesis IκB proteins. The demonstrates IκBα responsible for strong negative feedback allows fast turn-off response, whereas IκBβ -ɛ function to reduce system's oscillatory potential stabilize responses during longer stimulations. Bimodal signal-processing characteristics with respect stimulus duration are revealed shown generate specificity gene expression.