Polyglutamation of methotrexate. Is methotrexate a prodrug
作者： B A Chabner , C J Allegra , G A Curt , N J Clendeninn , J Baram
DOI: 10.1172/JCI112088
关键词: Methotrexate Toxicity 、 Methotrexate 、 Thymidylate synthase 、 Prodrug 、 Internal medicine 、 Tetrahydrofolate dehydrogenase 、 Pharmacology 、 Endocrinology 、 Biology 、 Intestinal mucosa
摘要: La polyglutamation est assuree par la folyl polyglutamyl synthetase. Leur etude decrit l'importance pharmacologique de du methotrexate
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