Diagnosis and treatment of vascular disease
作者： Jeanette Mccarthy
DOI:
关键词: Bioinformatics 、 Gene 、 Allele 、 Disease 、 Thrombospondin-2 、 THBS2 Gene 、 Biology 、 Thrombospondin 1 、 Vascular disease 、 Von Willebrand factor
摘要: The present invention is based at least in part on the discovery of polymorphisms within integrin beta 3 (ITGB3), von Willebrand factor (VWF), endothelin receptor type B (EDNRB), 2 (F2), P-selectin (SELP), thrombospondin 1 (THBS1), and (THBS2) genes. Accordingly, provides nucleic acid molecules having a nucleotide sequence an allelic variant ITGB3, VWF, EDNRB, F2, SELP, THBS1, or THBS2 gene. also methods for identifying specific alleles polymorphic regions gene, determining whether subject has risk developing disease which associated with allele region e.g., vascular disease, detection OR kits performing such methods. further who has, developing, disorder as candidate particular clinical course therapy diagnostic evaluation. selecting evaluation to treat disorder.
google.as 参考文章(21)
Hossein Jadvar, Robert C. Arzbaecher, Method and apparatus for detection of posterior ischemia ,(1988)
AJ Lee, FGR Fowkes, GDO Lowe, JM Connor, A Rumley, None, Fibrinogen, factor VII and PAI-1 genotypes and the risk of coronary and peripheral atherosclerosis: Edinburgh Artery Study. Thrombosis and Haemostasis. ,vol. 81, pp. 553- 560 ,(1999) , 10.1055/S-0037-1614523
Philip J. Harvey, Angela M. Keightley, Y. Miu Lam, Cherie Cameron, David Lillicrap, A single nucleotide polymorphism at nucleotide -1793 in the von Willebrand factor (VWF) regulatory region is associated with plasma VWF:Ag levels. British Journal of Haematology. ,vol. 109, pp. 349- 353 ,(2000) , 10.1046/J.1365-2141.2000.02000.X
M F Bonaldo, G Lennon, M B Soares, Normalization and subtraction: two approaches to facilitate gene discovery. Genome Research. ,vol. 6, pp. 791- 806 ,(1996) , 10.1101/GR.6.9.791
Frank M.VAN BOCKXMEER, Cyril D.S. MAMOTTE, Valerie BURKE, Roger R. TAYLOR, Angiotensin-converting enzyme gene polymorphism and premature coronary heart disease Clinical Science. ,vol. 99, pp. 247- 251 ,(2000) , 10.1042/CS20000018
Nena Aleksic, Harinder Juneja, Aaron R. Folsom, Chul Ahn, Eric Boerwinkle, Lloyd E. Chambless, Kenneth K. Wu, Platelet Pl(A2) allele and incidence of coronary heart disease: results from the Atherosclerosis Risk In Communities (ARIC) Study. Circulation. ,vol. 102, pp. 1901- 1905 ,(2000) , 10.1161/01.CIR.102.16.1901
RussellE. Baumann, AgnesH. Henschen, Linkage disequilibrium relationships among four polymorphisms within the human fibrinogen gene cluster. Human Genetics. ,vol. 94, pp. 165- 170 ,(1994) , 10.1007/BF00202863
Andrew Lennard, Pat Gorman, Martin Carrier, Samantha Griffiths, Hilary Scotney, Denise Sheer, Roberto Solari, Cloning and chromosome mapping of the human interleukin-1 receptor antagonist gene Cytokine. ,vol. 4, pp. 83- 89 ,(1992) , 10.1016/1043-4666(92)90041-O
Eric J. Topol, Jeanette McCarthy, Stacey Gabriel, David J. Moliterno, William J. Rogers, L. Kristin Newby, Matt Freedman, Jennifer Metivier, Ruth Cannata, Christopher J. O’Donnell, Kandice Kottke-Marchant, Gurunathan Murugesan, Edward F. Plow, Olga Stenina, George Q. Daley, Single Nucleotide Polymorphisms in Multiple Novel Thrombospondin Genes May Be Associated With Familial Premature Myocardial Infarction Circulation. ,vol. 104, pp. 2641- 2644 ,(2001) , 10.1161/HC4701.100910
Terry L LaBell, Dianna J McGookey Milewicz, Christine M Disteche, Peter H Byers, None, Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans. Genomics. ,vol. 12, pp. 421- 429 ,(1992) , 10.1016/0888-7543(92)90430-Z