Occult lymph node metastases in early stage vulvar carcinoma patients.

摘要: Abstract Objective. In early stage vulvar carcinoma patients, there is at trend towards individualized treatment in order to reduce morbidity and sequela following inguinal lymph node dissection. However, recurrences the groin are almost always fatal. present study, we address occult metastases squamous cell patients by using serial sectioning immunostaining of nodes a larger series relate findings clinical follow-up data. Methods. From 75 staged surgical FIGO I–III, 421 found negative hematoxylin & eosin (H&E) routine investigation were scrutinized. formalin-fixed paraffin-embedded tissues, sections cut with 150 μm interval stained H&E cytokeratin AE1/AE3. Two classes used describe amount tumor cells: 100 cells. Results. Positive AE1/AE3 staining was 25/421 (6%) nodes. Occult 17/75 (23%) patients. Correlation between metastasis site recurrence ( P  = 0.01). Twenty-eight percent had relapse. Conclusions. The study underlines importance search for micrometastases results do not suggest more thorough examination non-sentinel where sentinel thoroughly examined.