CONGENITAL MALFORMATIONS INDUCED IN RATS BY MATERNAL NUTRITIONAL DEFICIENCY: IV. CLEFT PALATE

摘要: Many theories have been advanced concerning the causes of cleft palate. Early attempted to explain this developmental defect by abnormal mechanical influences. Abnormal pressure mandible and tongue, 1 interposition extremities, 2 tumors 3 or supernumerary teeth 4 were blamed for failure union various parts which constitute normal Amniotic amniotic bands received special attention as possible facial clefts. 5 Hydrocephalus causing broadening base skull was also mentioned. 6 None these could be sufficiently supported, it is thought today that conditions once considered causative only accidental collateral abnormalities found in affected persons. Reports familial occurrence lip palate date back eighteenth century, 7 numerous instances families malformations occurred repeatedly through several generations