Effect of dietary fat level and sesamin on the polyunsaturated fatty acid metabolism in rats.
作者： Aya MIZUKUCHI , Rumi UMEDA-SAWADA , Osamu IGARASHI
DOI: 10.3177/JNSV.49.320
关键词: Sesamin 、 Vegetable oil 、 Soybean oil 、 Linoleic acid 、 Phospholipid 、 Internal medicine 、 Biology 、 Polyunsaturated fatty acid 、 Endocrinology 、 Arachidonic acid 、 Fatty acid
摘要: In this study, we examined the effects of sesamin and vegetable oil on concentrations polyunsaturated fatty acid (PUFA) lipids (triacylglycerol, free cholesterol, phospholipid), beta-oxidation enzyme activities in rat liver. Rats were fed a diet containing 5% (low-fat diet) or 20% (high-fat salad (rapeseed oil: soybean oil, 7:3) with without (0.5% w/w) for 4 wk. As result, linoleic (LA, n-6), alpha-linolenic (ALA, n-3), total PUFA liver increased significantly as result high-fat diet. groups, administration decreased LA, ALA, to almost same level low-fat group, while it dihomo-gamma-linolenic (DGLA, n-6) arachidonic (AA, n-6). The carnitine acyltransferase acyl-CoA dehydrogenase mitochondria enhanced by intake diet, further sesamin. Peroxisomal oxidase activity was also sesamin, not affected dietary fat level. These results suggest that suppressed increase hepatic concentration caused feeding through enhancing metabolism from LA ALA.
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