Intraperitoneal distribution imaging in ovarian cancer patients

摘要: Background/Aims: Optimal delivery of intraperitoneal (IP) chemotherapy is dependent on adequate drug distribution. An accurate understanding the limitations IP distribution critical if we are to improve cytotoxic through this route. Methods: Using repeated scintigraphic peritoneography investigated peritoneal fluid in patients receiving therapy. Both early (1–6 h) and late (24–48 h) images were performed. The cavity was divided into six regions; pouch Douglas, left right paracolic gutters, subphrenic spaces subhepatic space. each region classified as absent (0), faint (1) or intense (2). A total score calculated from summation values for regions. Distribution then graded according follows: Grade 0 = 0–3; 1 4–6; 2 7–9; 3 10–12. Results: Twenty-six participants included study: all 26 had imaging performed 21 these also imaging. Thirteen (50%) 15 (71%) grade respectively. most common abdominal regions show maldistribution spaces. Conclusions: This study highlights deficiencies following delivery, with majority demonstrating multiple uptake Future large clinical studies investigating should include analyses our optimal route.