Complementary DNA for human T-cell cyclophilin.
作者： B. Haendler , R. Hofer-Warbinek , E. Hofer
DOI: 10.1002/J.1460-2075.1987.TB04843.X
关键词: Blot 、 genomic DNA 、 Cyclophilin 、 Complementary DNA 、 Cyclosporin a 、 Peptide sequence 、 Molecular biology 、 Biology 、 Nucleic acid thermodynamics 、 Biochemistry 、 Southern blot
摘要: Complementary DNA encoding human cyclophilin, a specific cyclosporin A-binding protein, has been isolated from the leukemic T-cell line Jurkat and sequenced. Comparison of deduced amino acid sequence with previously determined bovine thymus cyclophilin reveals only three differences: an additional at carboxy terminus end two internal changes. RNA transfer blot analysis indicates mRNA size approximately 1 kb for cyclophilin. Phytohaemagglutinin phorbol myristate acetate induction T cells treated or not A affects marginally level mRNA. Southern genomic digested different restriction enzymes strongly suggests existence multigene family
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