Lens Epithelial Cell Proliferation

摘要: Cell proliferation in the vertebrate ocular lens is essential for its establishment, development and growth. Lens cell features very early morphogenesis results rapid tissue growth, but becomes increasingly restricted, both spatially temporally, with age. As established, so are defined growth zones characterised by polarised regions of subsequent fibre differentiation. These tightly regulated factors surrounding environment. Although epithelial persists throughout life, albeit at a markedly reduced rate increased age, majority cells adult remain quiescent. If perturbed, as result various pathologies, normal deregulated re-enter cycle; such cellular hyperplasia often compromises function subsequently cataract formation. Identifying key factors, understanding underlying mechanisms regulating proliferation, will further advance our aetiology cataracts that aberrant proliferation.