Quantifying the adverse effect of excessive heat on children: An elevated risk of hand, foot and mouth disease in hot days.

摘要: Abstract Background Hand, foot and mouth disease (HFMD) is a common childhood infection has become major public health issue in China. Considerable research focused on the role of meteorological factors such as temperature relative humidity HFMD development. However, no studies have specifically quantified impact another environmental agent, excessive heat, HFMD. The current study was designed to help address this gap. Methods Case-based surveillance data daily collected between 2010 2012 obtained from China CDC National Meteorological Information Center, respectively. Distributed lag nonlinear models were applied assess heat its variability across social-economic status age groups. Results After controlling effects several potential confounders, commonly hot days found positively affect burdens with risk ( RR ) peaking at around 6 days lag. Pearl-River Delta Region generally higher persisted longer than that remaining developing areas. Regarding inter-age group discrepancy, children aged 3–6 years old had highest under conditions whereas those greater 6 years lowest. structure extremely quite similar days, although effect these two kinds might vary regions. Conclusions This indicated significantly facilitating especially among 3–6 developed particularly practical important for area-and-age-targeted control programs context climate change urbanization.