The incidence of venous thromboembolism in thrombophilic children: a prospective cohort study

摘要: Antithrombin and protein C S defects, factor V Leiden mutation, G20210A prothrombin gene mutation are well-recognized risk factors for venous thromboembolism (VTE) in adults, especially during circumstantial situations such as trauma, immobilization, surgery, or oral contraceptive treatment. The relevance of these defects predisposing children to VTE is still undefined. In a prospective cohort study we assessed the incidence spontaneous period–related asymptomatic (aged 1-14 years), who were family members proband with an objectively diagnosed thromboembolic event documented single thrombophilic abnormality. We enrolled 143 from 63 families. Of them, 81 (56.6%) carriers inherited defect, whereas remaining 62 free known genetic acquired causes thrombophilia. mean observation period was 5 years (range, 1-8 years) each group. Thirty-one periods occurred group 20 noncarriers. Neither nor either 395 296 years, respectively. However, circumstances where most pediatric thromboses occur (insertion central lines, cancer, cardiovascular surgery) not encountered. conclusion, thrombotic otherwise healthy identified defect appears be very low. Common triggering conditions adults do seem increase carrying same defect. Accordingly, screening thrombophilia younger than 15 belong families thrombosis seems unjustified.