Nicotine administration enhances negative occasion setting in adolescent rats.

摘要: Substantial research has established that exposure to nicotine during adolescence can lead long-term changes in neural circuitry and behavior. However, relatively few studies have considered the effects of use on cognition this critical stage brain development. This is significant because influence cognitive performance may contribute development regular use. For example, improvements functioning increase perceived value smoking facilitate impulses smoke. To address this, present tested a form inhibitory learning adolescence. Specifically, adolescent rats were exposed as they trained negative occasion setting paradigm, which successful depends conditions under it is, or not, appropriate respond target stimulus. Here, we found administration enhances adolescents. In addition, increased amount orienting behavior directed toward stimulus, suggesting behavioral inhibition be attributed nicotine-induced increases attentional processing. These results help elucidate factors onset well continued products containing provide insight effectiveness interventions targeted at reducing prevalence smoking.